Uveoretinitis via IL-10 Murine Experimental Autoimmune Calcitonin Gene-Related Peptide Suppress Peritoneal Exudate Cells Treated with

Murine Experimental Autoimmune Calcitonin Gene-Related Peptide Suppress Peritoneal Exudate Cells Treated with

The effect of 17β-estradiol on gene expression of calcitonin gene-related peptide and some pro-inflammatory mediators in peripheral blood mononuclear cells from patients with pure menstrual migraine

Objective(s):The neuropeptide calcitonin gene-related peptide (CGRP) has long been postulated to play an integral role in the pathophysiology of migraine. Earlier studies showed that CGRP can stimulate the synthesis and release of nitric oxide (NO) and cytokines from trigeminal ganglion glial cells. The purpose of this study was to determine the effect of 17β-estradiol in regulation of CGRP exp...

Prevention of experimental autoimmune uveoretinitis by vasoactive intestinal peptide.

BACKGROUND Vasoactive intestinal peptide (VIP), a neuropeptide that is known to be present in lymphoid tissue microenvironments, shows prominent anti-inflammatory actions. OBJECTIVE To examine the potential effect of VIP on the development of experimental autoimmune uveoretinitis (EAU). DESIGN We immunized C57BL/6 mice with human interphotoreceptor retinoid-binding protein peptide 1-20 (h-I...

Calcitonin Gene-Related Peptide Effects on Phenotype and IL-12 Production of Monocyte-Derived Dendritic Cells in Rheumatoid Arthritis Patients

Objective(s) Recent studies on human indicate that the introduction of therapeutic use of tolerogenic dendritic cell (DC) for chronic inflammatory conditions is imminent. For the purpose of defining CGRP potency in tolerogenic DC production, we investigated the phenotype and IL-'2 production of DCs generated from the monocytes of rheumatoid arthritis (RA) patients in the presence of the calcit...

Interleukin-10 gene-transfected mature dendritic cells suppress murine experimental autoimmune optic neuritis.

PURPOSE We have reported that calcitonin gene-related peptide gene-transfected mature dendritic cells (mDC) suppress murine experimental autoimmune optic neuritis (EAON) and experimental autoimmune encephalitis (EAE) via interleukin-10 (IL-10) production. In our study, we examined whether IL-10-transfected mDC prevent development of EAON and EAE. METHODS A plasmid expressing mouse IL-10 was c...